Tissues are supported by dense and intricate networks of capillaries, hundreds passing through any square millimeter cross-section. Many studies have shown that capillary density decreases with age, which is perhaps another of the many results of faltering tissue maintenance due to the decline in stem cell activity, or alternatively, a specific dysregulation of the processes of angiogenesis at the small scale, resulting from inappropriate cellular reactions to rising levels of damage and chronic inflammation. Fewer capillaries means a lesser delivery of nutrients and oxygen, and we might well wonder to what degree this contributes to atrophy and dysfunction in energy hungry tissues such as muscles and the brain. In this context, consider of the loss of muscle mass and strength that occurs with aging, known as
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From https://johnher1.blogspot.com/2019/06/declining-microcirculation-as-important.html
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https://johnher1.wordpress.com/2019/06/14/declining-microcirculation-as-an-important-aspect-of-aging/
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